HORDB

ID: hor005375
Uniprot ID: P23465
Protein name: Diuretic hormone
Gene name: NA
Organism: Locusta migratoria (Migratory locust)
Family: Sauvagine/corticotropin-releasing factor/urotensin I family
Source: Animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Locusta (genus), Oedipodinae (subfamily), Acrididae (family), Acridoidea (superfamily), Acridomorpha, Acrididea (infraorder), Caelifera (suborder), Orthoptera (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region

Function: Regulation of fluid secretion. Stimulates primary urine secretion by Malpighian tubules and causes a dose-dependent stimulation of cAMP levels in the tubules.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P23465-F1.pdb

hor005375_AF2.pdb

hor005375_ESM.pdb

Mass:	616720	Formula:	C232H398N72O67S3
Absent amino acids:	CHTWY	Common amino acids:	L
pI:	10.72	Basic residues:	8
Polar residues:	6	Hydrophobic residues:	17
Hydrophobicity:	-33.7	Boman Index:	-10991
Half-Life:	30 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	112.39
Instability Index:	7572.17	Extinction Coefficient cystines:	0
Absorbance 280nm:	0